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Animal Models of Polyglutamine Diseases and Therapeutic Approaches
The dominant gain-of-function polyglutamine repeat diseases, in which the initiating mutation is known, allow development of models that recapitulate many aspects of human disease. To the extent that pathology is a consequence of disrupted fundamental cellular activities, one can effectively study s...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2658038/ https://ncbi.nlm.nih.gov/pubmed/18957429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R800065200 |
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