Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease

Huntington’s disease (HD) is associated with transcriptional dysregulation, and multiple studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring transcriptional balance and appropriate protein acetylation are therapeutically promising. To determine whether mor...

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Main Authors: Pallos, Judit, Bodai, Laszlo, Lukacsovich, Tamas, Purcell, Judith M., Steffan, Joan S., Thompson, Leslie Michels, Marsh, J. Lawrence
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581431/
https://ncbi.nlm.nih.gov/pubmed/18762557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn273
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