Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

We have previously demonstrated amelioration of Huntington's disease (HD)-related phenotypes in R6/2 transgenic mice in response to treatment with the novel histone deacetylase (HDAC) inhibitor 4b. Here we have measured the selectivity profiles of 4b and related compounds against class I and cl...

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Autori principali: Jia, Haiqun, Pallos, Judit, Jacques, Vincent, Lau, Alice, Tang, Bin, Cooper, Andrew, Syed, Adeela, Purcell, Judith, Chen, Yi, Sharma, Shefali, Sangrey, Gavin R., Darnell, Shayna B., Plasterer, Heather, Sadri-Vakili, Ghazaleh, Gottesfeld, Joel M., Thompson, Leslie M., Rusche, James R., Marsh, J. Lawrence, Thomas, Elizabeth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528106/
https://ncbi.nlm.nih.gov/pubmed/22590724
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