Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease

We have previously demonstrated amelioration of Huntington's disease (HD)-related phenotypes in R6/2 transgenic mice in response to treatment with the novel histone deacetylase (HDAC) inhibitor 4b. Here we have measured the selectivity profiles of 4b and related compounds against class I and cl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jia, Haiqun, Pallos, Judit, Jacques, Vincent, Lau, Alice, Tang, Bin, Cooper, Andrew, Syed, Adeela, Purcell, Judith, Chen, Yi, Sharma, Shefali, Sangrey, Gavin R., Darnell, Shayna B., Plasterer, Heather, Sadri-Vakili, Ghazaleh, Gottesfeld, Joel M., Thompson, Leslie M., Rusche, James R., Marsh, J. Lawrence, Thomas, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528106/
https://ncbi.nlm.nih.gov/pubmed/22590724
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados