A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila

The formation of polyglutamine-containing aggregates and inclusions are hallmarks of pathogenesis in Huntington's disease that can be recapitulated in model systems. Although the contribution of inclusions to pathogenesis is unclear, cell-based assays can be used to screen for chemical compound...

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Hauptverfasser: Apostol, Barbara L., Kazantsev, Alexsey, Raffioni, Simona, Illes, Katalin, Pallos, Judit, Bodai, Laszlo, Slepko, Natalia, Bear, James E., Gertler, Frank B., Hersch, Steven, Housman, David E., Marsh, J. Lawrence, Thompson, Leslie Michels
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2003
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC156307/
https://ncbi.nlm.nih.gov/pubmed/12730384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2628045100
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