Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells

Pathological degeneration of neurons in Huntington’s disease and associated neurodegenerative disorders is directly correlated with the expansion of CAG repeats encoding polyglutamines of extended length. The physical properties of extended polyglutamines and the intracellular consequences of expres...

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Bibliographic Details
Main Authors: Kazantsev, A., Preisinger, E., Dranovsky, A., Goldgaber, D., Housman, D.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC18046/
https://ncbi.nlm.nih.gov/pubmed/10500189
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