Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss

Neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau, are hallmarks of neurodegenerative diseases including Alzheimer disease (AD). In neurodegenerative diseases, neuronal dysfunction due to neuronal loss and synaptic loss accompanies NFT formation, suggesting that a process as...

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Dades bibliogràfiques
Autors principals: Kimura, Tetsuya, Fukuda, Tetsuya, Sahara, Naruhiko, Yamashita, Shunji, Murayama, Miyuki, Mizoroki, Tatsuya, Yoshiike, Yuji, Lee, Boyoung, Sotiropoulos, Ioannis, Maeda, Sumihiro, Takashima, Akihiko
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992302/
https://ncbi.nlm.nih.gov/pubmed/20921222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136630
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