Aggregation of Detergent-insoluble Tau Is Involved in Neuronal Loss but Not in Synaptic Loss

Neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau, are hallmarks of neurodegenerative diseases including Alzheimer disease (AD). In neurodegenerative diseases, neuronal dysfunction due to neuronal loss and synaptic loss accompanies NFT formation, suggesting that a process as...

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Detalhes bibliográficos
Main Authors: Kimura, Tetsuya, Fukuda, Tetsuya, Sahara, Naruhiko, Yamashita, Shunji, Murayama, Miyuki, Mizoroki, Tatsuya, Yoshiike, Yuji, Lee, Boyoung, Sotiropoulos, Ioannis, Maeda, Sumihiro, Takashima, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2992302/
https://ncbi.nlm.nih.gov/pubmed/20921222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.136630
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