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GABA(A) Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

Advanced age and mutations in the genes encoding amyloid precursor protein (APP) and presenilin (PS1) are two serious risk factors for Alzheimer's disease (AD). Finding common pathogenic changes originating from these risks may lead to a new therapeutic strategy. We observed a decline in memory...

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Detalhes bibliográficos
Main Authors: Yoshiike, Yuji, Kimura, Tetsuya, Yamashita, Shunji, Furudate, Hiroyuki, Mizoroki, Tatsuya, Murayama, Miyuki, Takashima, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515633/
https://ncbi.nlm.nih.gov/pubmed/18716656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003029
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