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Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau
To investigate how tau affects neuronal function during neurofibrillary tangle (NFT) formation, we examined the behavior, neural activity, and neuropathology of mice expressing wild-type human tau. Here, we demonstrate that aged (>20 months old) mice display impaired place learning and memory, ev...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2140104/ https://ncbi.nlm.nih.gov/pubmed/18007595 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601917 |
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