Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau

To investigate how tau affects neuronal function during neurofibrillary tangle (NFT) formation, we examined the behavior, neural activity, and neuropathology of mice expressing wild-type human tau. Here, we demonstrate that aged (>20 months old) mice display impaired place learning and memory, ev...

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Main Authors: Kimura, Tetsuya, Yamashita, Shunji, Fukuda, Tetsuya, Park, Jun-Mi, Murayama, Miyuki, Mizoroki, Tatsuya, Yoshiike, Yuji, Sahara, Naruhiko, Takashima, Akihiko
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140104/
https://ncbi.nlm.nih.gov/pubmed/18007595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601917
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