Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer’s Disease progression

Despite a key role of amyloid-beta (Aβ) in Alzheimer’s disease (AD), mechanisms that link Aβ plaques to tau neurofibrillary tangles and cognitive decline still remain poorly understood. The purpose of this study was to quantify proteins in the sarkosyl-insoluble brain proteome correlated with Aβ and...

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Bibliografske podrobnosti
izdano v:Proteomics
Main Authors: Hales, Chadwick M., Dammer, Eric B., Deng, Qiudong, Duong, Duc M., Gearing, Marla, Troncoso, Juan C., Thambisetty, Madhav, Lah, James J., Shulman, Joshua M., Levey, Allan I., Seyfried, Nicholas T.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462625/
https://ncbi.nlm.nih.gov/pubmed/27718298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pmic.201600057
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