U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

BACKGROUND: We recently identified U1 small nuclear ribonucleoprotein (snRNP) tangle-like aggregates and RNA splicing abnormalities in sporadic Alzheimer’s disease (AD). However little is known about snRNP biology in early onset AD due to autosomal dominant genetic mutations or trisomy 21 in Down sy...

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Main Authors: Hales, Chadwick M, Seyfried, Nicholas T, Dammer, Eric B, Duong, Duc, Yi, Hong, Gearing, Marla, Troncoso, Juan C, Mufson, Elliott J, Thambisetty, Madhav, Levey, Allan I, Lah, James J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022210/
https://ncbi.nlm.nih.gov/pubmed/24773620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-15
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