U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer’s disease due to autosomal dominant genetic mutations and trisomy 21

BACKGROUND: We recently identified U1 small nuclear ribonucleoprotein (snRNP) tangle-like aggregates and RNA splicing abnormalities in sporadic Alzheimer’s disease (AD). However little is known about snRNP biology in early onset AD due to autosomal dominant genetic mutations or trisomy 21 in Down sy...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hales, Chadwick M, Seyfried, Nicholas T, Dammer, Eric B, Duong, Duc, Yi, Hong, Gearing, Marla, Troncoso, Juan C, Mufson, Elliott J, Thambisetty, Madhav, Levey, Allan I, Lah, James J
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2014
Pynciau:
Short Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022210/
https://ncbi.nlm.nih.gov/pubmed/24773620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-15
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