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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates
Sequence-specific nucleated protein aggregation is closely linked to the pathogenesis of most neurodegenerative diseases and constitutes the molecular basis of prion formation1. Here we report that fibrillar polyglutamine peptide aggregates can be internalized by mammalian cells in culture where the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2757079/ https://ncbi.nlm.nih.gov/pubmed/19151706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1830 |
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