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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

Sequence-specific nucleated protein aggregation is closely linked to the pathogenesis of most neurodegenerative diseases and constitutes the molecular basis of prion formation1. Here we report that fibrillar polyglutamine peptide aggregates can be internalized by mammalian cells in culture where the...

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Detalhes bibliográficos
Main Authors: Ren, Pei-Hsien, Lauckner, Jane E., Kachirskaia, Ioulia, Heuser, John E., Melki, Ronald, Kopito, Ron R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757079/
https://ncbi.nlm.nih.gov/pubmed/19151706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1830
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