Caricamento...

Nuclear Aggregation of Polyglutamine-expanded Ataxin-3: FRAGMENTS ESCAPE THE CYTOPLASMIC QUALITY CONTROL

Expansion of a polymorphic polyglutamine segment is the common denominator of neurodegenerative polyglutamine diseases. The expanded proteins typically accumulate in large intranuclear inclusions and induce neurodegeneration. However, the mechanisms that determine the subcellular site and rate of in...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Breuer, Peter, Haacke, Annette, Evert, Bernd O., Wüllner, Ullrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825449/
https://ncbi.nlm.nih.gov/pubmed/20064935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036335
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !