Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone

Ubiquitin-specific protease 19 (USP19) is one of the deubiquitinating enzymes (DUBs) involved in regulating the ubiquitination status of substrate proteins. There are two major isoforms of USP19 with distinct C-termini; the USP19_a isoform has a transmembrane domain for anchoring to the endoplasmic...

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Vydáno v:PLoS One
Hlavní autoři: He, Wen-Tian, Zheng, Xue-Ming, Zhang, Yu-Hang, Gao, Yong-Guang, Song, Ai-Xin, van der Goot, Françoise Gisou, Hu, Hong-Yu
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726498/
https://ncbi.nlm.nih.gov/pubmed/26808260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147515
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