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Nuclear Aggregation of Polyglutamine-expanded Ataxin-3: FRAGMENTS ESCAPE THE CYTOPLASMIC QUALITY CONTROL

Expansion of a polymorphic polyglutamine segment is the common denominator of neurodegenerative polyglutamine diseases. The expanded proteins typically accumulate in large intranuclear inclusions and induce neurodegeneration. However, the mechanisms that determine the subcellular site and rate of in...

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Bibliografiske detaljer
Main Authors: Breuer, Peter, Haacke, Annette, Evert, Bernd O., Wüllner, Ullrich
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825449/
https://ncbi.nlm.nih.gov/pubmed/20064935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036335
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