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Nuclear Aggregation of Polyglutamine-expanded Ataxin-3: FRAGMENTS ESCAPE THE CYTOPLASMIC QUALITY CONTROL
Expansion of a polymorphic polyglutamine segment is the common denominator of neurodegenerative polyglutamine diseases. The expanded proteins typically accumulate in large intranuclear inclusions and induce neurodegeneration. However, the mechanisms that determine the subcellular site and rate of in...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825449/ https://ncbi.nlm.nih.gov/pubmed/20064935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.036335 |
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