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Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation
CNS neurons are endowed with the ability to recover from cytotoxic insults associated with the accumulation of proteinaceous aggregates in mouse models of polyglutamine disease, but the cellular mechanism underlying this phenomenon is unknown. Here, we show that autophagy is essential for the elimin...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2005
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1201602/ https://ncbi.nlm.nih.gov/pubmed/16141322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505801102 |
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