Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

CNS neurons are endowed with the ability to recover from cytotoxic insults associated with the accumulation of proteinaceous aggregates in mouse models of polyglutamine disease, but the cellular mechanism underlying this phenomenon is unknown. Here, we show that autophagy is essential for the elimin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Iwata, Atsushi, Christianson, John C., Bucci, Mirella, Ellerby, Lisa M., Nukina, Nobuyuki, Forno, Lysia S., Kopito, Ron R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2005
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201602/
https://ncbi.nlm.nih.gov/pubmed/16141322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0505801102
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