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A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells
Trinucleotide CAG repeat expansion in the coding region of genes has a propensity to form polyglutamine (polyQ) aggregates that contribute to neuronal disorders. Strategies in elevating autophagy to disintegrate the insoluble aggregates without injuring cells have become a major goal for therapy. In...
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| Publicado no: | Drug Des Devel Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028077/ https://ncbi.nlm.nih.gov/pubmed/27695292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S111903 |
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