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A triazole derivative elicits autophagic clearance of polyglutamine aggregation in neuronal cells

Trinucleotide CAG repeat expansion in the coding region of genes has a propensity to form polyglutamine (polyQ) aggregates that contribute to neuronal disorders. Strategies in elevating autophagy to disintegrate the insoluble aggregates without injuring cells have become a major goal for therapy. In...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Hsieh, Chang Heng, Lee, Li-Ching, Leong, Wai-Yin, Yang, Tsai-Chen, Yao, Ching-Fa, Fang, Kang
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028077/
https://ncbi.nlm.nih.gov/pubmed/27695292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S111903
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