Fibrillar Structure and Charge Determine the Interaction of Polyglutamine Protein Aggregates with the Cell Surface

The pathogenesis of most neurodegenerative diseases, including transmissible diseases like prion encephalopathy, inherited disorders like Huntington disease, and sporadic diseases like Alzheimer and Parkinson diseases, is intimately linked to the formation of fibrillar protein aggregates. It is beco...

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Bibliografiske detaljer
Main Authors: Trevino, R. Sean, Lauckner, Jane E., Sourigues, Yannick, Pearce, Margaret M., Bousset, Luc, Melki, Ronald, Kopito, Ron R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436181/
https://ncbi.nlm.nih.gov/pubmed/22753412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372474
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