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The Aggregation Free Energy Landscapes of Polyglutamine Repeats

Aggregates of proteins containing polyglutamine (polyQ) repeats are strongly associated with several neurodegenerative diseases. The length of the repeats correlates with the severity of the disease. Previous studies have shown that pure polyQ peptides aggregate by nucleated growth polymerization an...

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Publicado en:J Am Chem Soc
Main Authors: Chen, Mingchen, Tsai, MinYeh, Zheng, Weihua, Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5803750/
https://ncbi.nlm.nih.gov/pubmed/27786478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b08665
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