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Free energy landscapes for initiation and branching of protein aggregation

Experiments on artificial multidomain protein constructs have probed the early stages of aggregation processes, but structural details of the species that initiate aggregation remain elusive. Using the associative-memory, water-mediated, structure and energy model known as AWSEM, a transferable coar...

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Detalhes bibliográficos
Main Authors: Zheng, Weihua, Schafer, Nicholas P., Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870682/
https://ncbi.nlm.nih.gov/pubmed/24284165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320483110
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