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Free energy landscapes for initiation and branching of protein aggregation

Experiments on artificial multidomain protein constructs have probed the early stages of aggregation processes, but structural details of the species that initiate aggregation remain elusive. Using the associative-memory, water-mediated, structure and energy model known as AWSEM, a transferable coar...

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Detalles Bibliográficos
Main Authors: Zheng, Weihua, Schafer, Nicholas P., Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3870682/
https://ncbi.nlm.nih.gov/pubmed/24284165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320483110
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