Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of genes required for cell proliferation and differentiation. Here we show that targeted disruption of bot...

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Autors principals: Lagger, Gerda, O’Carroll, Dónal, Rembold, Martina, Khier, Harald, Tischler, Julia, Weitzer, Georg, Schuettengruber, Bernd, Hauser, Christoph, Brunmeir, Reinhard, Jenuwein, Thomas, Seiser, Christian
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126040/
https://ncbi.nlm.nih.gov/pubmed/12032080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.11.2672
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