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Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

Histone deacetylases (HDACs) modulate chromatin structure and transcription, but little is known about their function in mammalian development. HDAC1 was implicated previously in the repression of genes required for cell proliferation and differentiation. Here we show that targeted disruption of bot...

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Udgivet i:EMBO J
Principais autores: Lagger, Gerda, O’Carroll, Dónal, Rembold, Martina, Khier, Harald, Tischler, Julia, Weitzer, Georg, Schuettengruber, Bernd, Hauser, Christoph, Brunmeir, Reinhard, Jenuwein, Thomas, Seiser, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126040/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12032080/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.11.2672
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