Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1

The members of the Sp1 transcription factor family can act as both negative and positive regulators of gene expression. Here we show that Sp1 can be a target for histone deacetylase 1 (HDAC1)-mediated transcriptional repression. The histone deacetylase inhibitor trichostatin A activates the chromoso...

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Hlavní autoři: Doetzlhofer, Angelika, Rotheneder, Hans, Lagger, Gerda, Koranda, Manfred, Kurtev, Vladislav, Brosch, Gerald, Wintersberger, Erhard, Seiser, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC84392/
https://ncbi.nlm.nih.gov/pubmed/10409740
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