Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1

The members of the Sp1 transcription factor family can act as both negative and positive regulators of gene expression. Here we show that Sp1 can be a target for histone deacetylase 1 (HDAC1)-mediated transcriptional repression. The histone deacetylase inhibitor trichostatin A activates the chromoso...

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Bibliografiske detaljer
Main Authors: Doetzlhofer, Angelika, Rotheneder, Hans, Lagger, Gerda, Koranda, Manfred, Kurtev, Vladislav, Brosch, Gerald, Wintersberger, Erhard, Seiser, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84392/
https://ncbi.nlm.nih.gov/pubmed/10409740
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