Histone Deacetylase 1 Can Repress Transcription by Binding to Sp1

The members of the Sp1 transcription factor family can act as both negative and positive regulators of gene expression. Here we show that Sp1 can be a target for histone deacetylase 1 (HDAC1)-mediated transcriptional repression. The histone deacetylase inhibitor trichostatin A activates the chromoso...

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Main Authors: Doetzlhofer, Angelika, Rotheneder, Hans, Lagger, Gerda, Koranda, Manfred, Kurtev, Vladislav, Brosch, Gerald, Wintersberger, Erhard, Seiser, Christian
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1999
主題:
Transcriptional Regulation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC84392/
https://ncbi.nlm.nih.gov/pubmed/10409740
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