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Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

We have investigated the ability of dexamethasone to regulate interleukin-1β (IL-1β)-induced gene expression, histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity. Low concentrations of dexamethasone (10(−10) M) repress IL-1β-stimulated granulocyte-macrophage colony-stimulating fa...

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Detalhes bibliográficos
Main Authors: Ito, Kazuhiro, Barnes, Peter J., Adcock, Ian M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC88765/
https://ncbi.nlm.nih.gov/pubmed/10958685
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