DNA cleavage by Type ISP Restriction–Modification enzymes is initially targeted to the 3′-5′ strand

por van Aelst, Kara, Šišáková, Eva, Szczelkun, Mark D.
Publicado 2013

Mapping DNA cleavage by the Type ISP restriction-modification enzymes following long-range communication between DNA sites in different orientations

por van Aelst, Kara, Saikrishnan, Kayarat, Szczelkun, Mark D.
Publicado en Nucleic Acids Res (2015)

Dissociation from DNA of Type III Restriction–Modification enzymes during helicase-dependent motion and following endonuclease activity

por Tóth, Júlia, van Aelst, Kara, Salmons, Hannah, Szczelkun, Mark D.
Publicado 2012

The Type ISP Restriction–Modification enzymes LlaBIII and LlaGI use a translocation–collision mechanism to cleave non-specific DNA distant from their recognition sites

por Šišáková, Eva, van Aelst, Kara, Diffin, Fiona M., Szczelkun, Mark D.
Publicado 2013

Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

por Kulkarni, Manasi, Nirwan, Neha, van Aelst, Kara, Szczelkun, Mark D., Saikrishnan, Kayarat
Publicado en Nucleic Acids Res (2016)

DNA cleavage site selection by Type III restriction enzymes provides evidence for head-on protein collisions following 1D bidirectional motion

por Schwarz, Friedrich W., van Aelst, Kara, Tóth, Júlia, Seidel, Ralf, Szczelkun, Mark D.
Publicado 2011

The Effect of DNA Topology on Observed Rates of R-Loop Formation and DNA Strand Cleavage by CRISPR Cas12a

por van Aelst, Kara, Martínez-Santiago, Carlos J., Cross, Stephen J., Szczelkun, Mark D.
Publicado en Genes (Basel) (2019)

Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat

por van Aelst, Kara, Tóth, Júlia, Ramanathan, Subramanian P., Schwarz, Friedrich W., Seidel, Ralf, Szczelkun, Mark D.
Publicado 2010

The helicase-like domains of Type III restriction enzymes trigger long-range diffusion along DNA

por Schwarz, Friedrich W., Tóth, Júlia, van Aelst, Kara, Cui, Guanshen, Clausing, Sylvia, Szczelkun, Mark D., Seidel, Ralf
Publicado 2013

Type III restriction enzymes communicate in 1D without looping between their target sites

por Ramanathan, Subramanian P., van Aelst, Kara, Sears, Alice, Peakman, Luke J., Diffin, Fiona M., Szczelkun, Mark D., Seidel, Ralf
Publicado 2009

Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes

por Chand, Mahesh Kumar, Nirwan, Neha, Diffin, Fiona M., van Aelst, Kara, Kulkarni, Manasi, Pernstich, Christian, Szczelkun, Mark D., Saikrishnan, Kayarat
Publicado en Nat Chem Biol (2015)

5′ modifications to CRISPR–Cas9 gRNA can change the dynamics and size of R-loops and inhibit DNA cleavage

por Mullally, Grace, van Aelst, Kara, Naqvi, Mohsin M, Diffin, Fiona M, Karvelis, Tautvydas, Gasiunas, Giedrius, Siksnys, Virginijus, Szczelkun, Mark D
Publicado en Nucleic Acids Res (2020)