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Type III restriction enzymes communicate in 1D without looping between their target sites

To cleave DNA, Type III restriction enzymes must communicate the relative orientation of two asymmetric recognition sites over hundreds of base pairs. The basis of this long-distance communication, for which ATP hydrolysis by their helicase domains is required, is poorly understood. Several conflict...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ramanathan, Subramanian P., van Aelst, Kara, Sears, Alice, Peakman, Luke J., Diffin, Fiona M., Szczelkun, Mark D., Seidel, Ralf
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633214/
https://ncbi.nlm.nih.gov/pubmed/19181848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807193106
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