Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes

Endonucleolytic double-strand DNA break production requires separate strand cleavage events. Although catalytic mechanisms for simple dimeric endonucleases are available, there are many complex nuclease machines which are poorly understood in comparison. Here we studied the single polypeptide Type I...

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Publicado no:Nat Chem Biol
Main Authors: Chand, Mahesh Kumar, Nirwan, Neha, Diffin, Fiona M., van Aelst, Kara, Kulkarni, Manasi, Pernstich, Christian, Szczelkun, Mark D., Saikrishnan, Kayarat
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636054/
https://ncbi.nlm.nih.gov/pubmed/26389736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1926
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