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Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Engineering restriction enzymes with new sequence specificity has been an unaccomplished challenge, presumably because of the complexity of target recognition. Here we report detailed analyses of target recognition by Type ISP restriction-modification enzymes. We determined the structure of the Type...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Kulkarni, Manasi, Nirwan, Neha, van Aelst, Kara, Szczelkun, Mark D., Saikrishnan, Kayarat
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872093/
https://ncbi.nlm.nih.gov/pubmed/26975655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw154
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