Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Engineering restriction enzymes with new sequence specificity has been an unaccomplished challenge, presumably because of the complexity of target recognition. Here we report detailed analyses of target recognition by Type ISP restriction-modification enzymes. We determined the structure of the Type...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Kulkarni, Manasi, Nirwan, Neha, van Aelst, Kara, Szczelkun, Mark D., Saikrishnan, Kayarat
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2016
Materias:
Structural Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872093/
https://ncbi.nlm.nih.gov/pubmed/26975655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw154
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