Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes

Engineering restriction enzymes with new sequence specificity has been an unaccomplished challenge, presumably because of the complexity of target recognition. Here we report detailed analyses of target recognition by Type ISP restriction-modification enzymes. We determined the structure of the Type...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Kulkarni, Manasi, Nirwan, Neha, van Aelst, Kara, Szczelkun, Mark D., Saikrishnan, Kayarat
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872093/
https://ncbi.nlm.nih.gov/pubmed/26975655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw154
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