Rat traps: filling the toolbox for manipulating the rat genome

Por van Boxtel, Ruben, Cuppen, Edwin
Publicado em 2010

SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition

Por Vervoort, Stephin J., Lourenço, Ana Rita, van Boxtel, Ruben, Coffer, Paul J.
Publicado em 2013

Improved generation of rat gene knockouts by target-selected mutagenesis in mismatch repair-deficient animals

Por van Boxtel, Ruben, Toonen, Pim W, Verheul, Mark, van Roekel, Henk S, Nijman, Isaac J, Guryev, Victor, Cuppen, Edwin
Publicado em 2008

Homozygous and Heterozygous p53 Knockout Rats Develop Metastasizing Sarcomas with High Frequency

Por van Boxtel, Ruben, Kuiper, Raoul V., Toonen, Pim W., van Heesch, Sebastiaan, Hermsen, Roel, de Bruin, Alain, Cuppen, Edwin
Publicado em 2011

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

Por van Keimpema, Martine, Grüneberg, Leonie J., Mokry, Michal, van Boxtel, Ruben, Koster, Jan, Coffer, Paul J., Pals, Steven T., Spaargaren, Marcel
Publicado no Blood (2014)

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

Por van Keimpema, Martine, Grüneberg, Leonie J., Mokry, Michal, van Boxtel, Ruben, van Zelm, Menno C., Coffer, Paul, Pals, Steven T., Spaargaren, Marcel
Publicado no Blood (2015)

Deficiency or inhibition of lysophosphatidic acid receptor 1 protects against hyperoxia-induced lung injury in neonatal rats

Por Chen, Xueyu, Walther, Frans J, van Boxtel, Ruben, Laghmani, El Houari, Sengers, Rozemarijn M A, Folkerts, Gert, DeRuiter, Marco C., Cuppen, Edwin, Wagenaar, Gerry T M
Publicado no Acta Physiol (Oxf) (2015)

Melanocortin Receptor 4 Deficiency Affects Body Weight Regulation, Grooming Behavior, and Substrate Preference in the Rat

Por Mul, Joram D., van Boxtel, Ruben, Bergen, Dylan J.M., Brans, Maike A.D., Brakkee, Jan H., Toonen, Pim W., Garner, Keith M., Adan, Roger A.H., Cuppen, Edwin
Publicado em 2012

Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling

Por Eijkelenboom, Astrid, Mokry, Michal, de Wit, Elzo, Smits, Lydia M, Polderman, Paulien E, van Triest, Miranda H, van Boxtel, Ruben, Schulze, Almut, de Laat, Wouter, Cuppen, Edwin, Burgering, Boudewijn M T
Publicado em 2013

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Por Fumagalli, Arianna, Drost, Jarno, Suijkerbuijk, Saskia J. E., van Boxtel, Ruben, de Ligt, Joep, Offerhaus, G. Johan, Begthel, Harry, Beerling, Evelyne, Tan, Ee Hong, Sansom, Owen J., Cuppen, Edwin, Clevers, Hans, van Rheenen, Jacco
Publicado no Proc Natl Acad Sci U S A (2017)

Genomic landscape of rat strain and substrain variation

Por Hermsen, Roel, de Ligt, Joep, Spee, Wim, Blokzijl, Francis, Schäfer, Sebastian, Adami, Eleonora, Boymans, Sander, Flink, Stephen, van Boxtel, Ruben, van der Weide, Robin H, Aitman, Tim, Hübner, Norbert, Simonis, Marieke, Tabakoff, Boris, Guryev, Victor, Cuppen, Edwin
Publicado no BMC Genomics (2015)

Identification of multipotent luminal progenitor cells in human prostate organoid cultures

Por Karthaus, Wouter R., Iaquinta, Phillip J., Drost, Jarno, Gracanin, Ana, van Boxtel, Ruben, Wongvipat, John, Dowling, Catherine M., Gao, Dong, Begthel, Harry, Sachs, Norman, Vries, Robert G.J., Cuppen, Edwin, Chen, Yu, Sawyers, Charles L., Clevers, Hans C.
Publicado no Cell (2014)

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model­

Por Homberg, Judith R., Olivier, Jocelien D. A., VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K., Karel, Peter, Shan, Ling, van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R., Cuppen, Edwin, Ellenbroek, Bart A.
Publicado no Dis Model Mech (2016)

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Por Behjati, Sam, Huch, Meritxell, van Boxtel, Ruben, Karthaus, Wouter, Wedge, David C, Tamuri, Asif U, Martincorena, Inigo, Petljak, Mia, Alexandrov, Ludmil B, Gundem, Gunes, Tarpey, Patrick S, Roerink, Sophie, Blokker, Joyce, Maddison, Mark, Mudie, Laura, Robinson, Ben, Nik-Zainal, Serena, Campbell, Peter, Goldman, Nick, van de Wetering, Marc, Cuppen, Edwin, Clevers, Hans, Stratton, Michael R
Publicado no Nature (2014)

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Por Huch, Meritxell, Gehart, Helmuth, van Boxtel, Ruben, Hamer, Karien, Blokzijl, Francis, Verstegen, Monique M.A., Ellis, Ewa, van Wenum, Martien, Fuchs, Sabine A., de Ligt, Joep, van de Wetering, Marc, Sasaki, Nobuo, Boers, Susanne J., Kemperman, Hans, de Jonge, Jeroen, Ijzermans, Jan N.M., Nieuwenhuis, Edward E.S., Hoekstra, Ruurdtje, Strom, Stephen, Vries, Robert R.G., van der Laan, Luc J.W., Cuppen, Edwin, Clevers, Hans
Publicado no Cell (2015)

Tissue-specific mutation accumulation in human adult stem cells during life

Por Blokzijl, Francis, de Ligt, Joep, Jager, Myrthe, Sasselli, Valentina, Roerink, Sophie, Sasaki, Nobuo, Huch, Meritxell, Boymans, Sander, Kuijk, Ewart, Prins, Pjotr, Nijman, Isaac J., Martincorena, Inigo, Mokry, Michal, Wiegerinck, Caroline L., Middendorp, Sabine, Sato, Toshiro, Schwank, Gerald, Nieuwenhuis, Edward E. S., Verstegen, Monique M. A., van der Laan, Luc J. W., de Jonge, Jeroen, IJzermans, Jan N. M., Vries, Robert G., van de Wetering, Marc, Stratton, Michael R., Clevers, Hans, Cuppen, Edwin, van Boxtel, Ruben
Publicado no Nature (2016)

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Por Boj, Sylvia F., Hwang, Chang-Il, Baker, Lindsey A., Chio, Iok In Christine, Engle, Dannielle D., Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S., Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H., van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D., Wilson, John P., Feigin, Michael E., Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M., Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N., Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H.M., Molenaar, I. Quintus, Borel Rinkes, Inne H., Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J., Iacobuzio-Donahue, Christine, Leach, Steven D., Pappin, Darryl J., Hammell, Molly, Klimstra, David S., Basturk, Olca, Hruban, Ralph H., Offerhaus, George Johan, Vries, Robert G.J., Clevers, Hans, Tuveson, David A.
Publicado no Cell (2014)