Identification of multipotent luminal progenitor cells in human prostate organoid cultures

The prostate gland consists of basal and luminal cells arranged as pseudo-stratified epithelium. In tissue recombination models, only basal cells reconstitute a complete prostate gland, yet murine lineage-tracing experiments show that luminal cells generate basal cells. It has remained challenging t...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Karthaus, Wouter R., Iaquinta, Phillip J., Drost, Jarno, Gracanin, Ana, van Boxtel, Ruben, Wongvipat, John, Dowling, Catherine M., Gao, Dong, Begthel, Harry, Sachs, Norman, Vries, Robert G.J., Cuppen, Edwin, Chen, Yu, Sawyers, Charles L., Clevers, Hans C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772677/
https://ncbi.nlm.nih.gov/pubmed/25201529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.08.017
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