Molecular and biochemical pharmacology of the histamine H(4) receptor

par Leurs, Rob, Chazot, Paul L, Shenton, Fiona C, Lim, Herman D, de Esch, Iwan JP
Publié 2009

Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs

par Stadel, Rebecca, Carpenter, Amanda B., Nalwalk, Julia W., de Esch, Iwan J.P., Janssen, Elwin, Hough, Lindsay B.
Publié 2010

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT(3)A and 5-HT(3)AB receptors

par Thompson, Andrew J., Verheij, Mark H.P., Verbeek, Joost, Windhorst, Albert D., de Esch, Iwan J.P., Lummis, Sarah C.R.
Publié dans Neuropharmacology (2014)

KLIFS: a structural kinase-ligand interaction database

par Kooistra, Albert J., Kanev, Georgi K., van Linden, Oscar P.J., Leurs, Rob, de Esch, Iwan J.P., de Graaf, Chris
Publié dans Nucleic Acids Res (2016)

A fluorescent approach for identifying P2X1 ligands

par Ruepp, Marc-David, Brozik, James A., de Esch, Iwan J.P., Farndale, Richard W., Murrell-Lagnado, Ruth D., Thompson, Andrew J.
Publié dans Neuropharmacology (2015)

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

par Akdemir, Atilla, Edink, Ewald, Thompson, Andrew J., Lummis, Sarah C.R., Kooistra, Albert J., de Graaf, Chris, de Esch, Iwan J.P.
Publié 2012

Exploring the Effect of Cyclization of Histamine H(1) Receptor Antagonists on Ligand Binding Kinetics

par Wang, Zhiyong, Bosma, Reggie, Kuhne, Sebastiaan, van den Bor, Jelle, Garabitian, Wrej, Vischer, Henry F., Wijtmans, Maikel, Leurs, Rob, de Esch, Iwan J.P.
Publié dans ACS Omega (2021)

Pharmacological characterization of the new histamine H(4) receptor agonist VUF 8430

par Lim, Herman D, Adami, Maristella, Guaita, Elena, Werfel, Thomas, Smits, Rogier A, de Esch, Iwan JP, Bakker, Remko A, Gutzmer, Ralf, Coruzzi, Gabriella, Leurs, Rob
Publié 2009

EPHA4 is overexpressed but not functionally active in Sézary syndrome

par Hameetman, Liesbeth, van der Fits, Leslie, Zoutman, Willem H., Out-Luiting, Jacoba J., Siegal, Gregg, de Esch, Iwan J.P., Vermeer, Maarten H., Tensen, Cornelis P.
Publié dans Oncotarget (2015)

CC12, A High Affinity Ligand for (3)H-Cimetidine Binding, is an Improgan Antagonist

par Hough, Lindsay B., Nalwalk, Julia W., Phillips, James G., Kern, Brian, Shan, Zhixing, Wentland, Mark P., de Esch, Iwan J.P., Janssen, Elwin, Barr, Travis, Stadel, Rebecca
Publié 2007

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure

par Jansen, Chimed, Wang, Huanchen, Kooistra, Albert J., de Graaf, Chris, Orrling, Kristina, Tenor, Hermann, Seebeck, Thomas, Bailey, David, de Esch, Iwan J.P., Ke, Hengming, Leurs, Rob
Publié 2013

In Silico Veritas: The Pitfalls and Challenges of Predicting GPCR-Ligand Interactions

par Roumen, Luc, Sanders, Marijn P.A., Vroling, Bas, de Esch, Iwan J.P., de Vlieg, Jacob, Leurs, Rob, Klomp, Jan P.G., Nabuurs, Sander B., de Graaf, Chris
Publié 2011

Non-competitive antagonism and inverse agonism as mechanism of action of non-peptidergic antagonists at primate and rodent CXCR3 chemokine receptors

par Verzijl, Dennis, Storelli, Stefania, Scholten, Danny, Bosch, Leontien, Reinhart, Todd A., Streblow, Daniel N., Tensen, Cornelis P., Fitzsimons, Carlos P., Zaman, Guido J.R., Pease, James E., de Esch, Iwan J.P., Smit, Martine J., Leurs, Rob
Publié 2008

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H(4) and the ion channel serotonin 5-HT(3A)

par Verheij, Mark H.P., de Graaf, Chris, de Kloe, Gerdien E., Nijmeijer, Saskia, Vischer, Henry F., Smits, Rogier A., Zuiderveld, Obbe P., Hulscher, Saskia, Silvestri, Linda, Thompson, Andrew J., van Muijlwijk-Koezen, Jacqueline E., Lummis, Sarah C.R., Leurs, Rob, de Esch, Iwan J.P.
Publié 2011

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

par Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Publié dans Int J Parasitol Drugs Drug Resist (2019)