Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

We report the evaluation of 265 compounds from a PDE-focused library for their antischistosomal activity, assessed in vitro using Schistosoma mansoni. Of the tested compounds, 171 (64%) displayed selective in vitro activity, with 16 causing worm hypermotility/spastic contractions and 41 inducing var...

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Détails bibliographiques
Publié dans:Int J Parasitol Drugs Drug Resist
Auteurs principaux: Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., Seif el-Din, Sayed H., García-Rubia, Alfonso, Sebastián-Pérez, Victor, Blaazer, Antoni R., de Heuvel, Erik, Sijm, Maarten, Zheng, Yang, Salado, Irene G., Munday, Jane C., Maes, Louis, de Esch, Iwan J.P., Sterk, Geert J., Augustyns, Koen, Leurs, Rob, Gil, Carmen, De Koning, Harry P.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6350229/
https://ncbi.nlm.nih.gov/pubmed/30669086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpddr.2019.01.001
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