Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here. The in vivo studies in a S. mansoni mouse model show...

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Bibliographic Details
Published in:J Enzyme Inhib Med Chem
Main Authors: Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E., Botros, Sanaa S., Gil, Carmen
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717570/
https://ncbi.nlm.nih.gov/pubmed/31939312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1712595
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