Altered Amyloid-β Metabolism and Deposition in Genomic-based β-Secretase Transgenic Mice

Por Chiocco, Matthew J., Kulnane, Laura Shapiro, Younkin, Linda, Younkin, Steve, Evin, Geneviève, Lamb, Bruce T.
Publicado em 2004

Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease

Por Kawarabayashi, Takeshi, Younkin, Linda H., Saido, Takaomi C., Shoji, Mikio, Ashe, Karen Hsiao, Younkin, Steven G.
Publicado no J Neurosci (2001)

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

Por Kotilinek, Linda A., Bacskai, Brian, Westerman, Marcus, Kawarabayashi, Takeshi, Younkin, Linda, Hyman, Bradley T., Younkin, Steven, Ashe, Karen H.
Publicado no J Neurosci (2002)

Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

Por Niwa, Kiyoshi, Younkin, Linda, Ebeling, Christine, Turner, Sherry K., Westaway, David, Younkin, Steven, Ashe, Karen Hsiao, Carlson, George A., Iadecola, Costantino
Publicado em 2000

Rodent Aβ Modulates the Solubility and Distribution of Amyloid Deposits in Transgenic Mice()

Por Jankowsky, Joanna L., Younkin, Linda H., Gonzales, Victoria, Fadale, Daniel J., Slunt, Hilda H., Lester, Henry A., Younkin, Steven G., Borchelt, David R.
Publicado no J Biol Chem (2007)

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

Por Park, Laibaik, Zhou, Ping, Pitstick, Rose, Capone, Carmen, Anrather, Josef, Norris, Erin H., Younkin, Linda, Younkin, Steven, Carlson, George, McEwen, Bruce S., Iadecola, Costantino
Publicado em 2008

Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

Por Holth, Jerrah K., Bomben, Valerie C., Reed, J. Graham, Inoue, Taeko, Younkin, Linda, Younkin, Steven G., Pautler, Robia G., Botas, Juan, Noebels, Jeffrey L.
Publicado em 2013

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

Por Westerman, Marcus A., Cooper-Blacketer, Deirdre, Mariash, Ami, Kotilinek, Linda, Kawarabayashi, Takeshi, Younkin, Linda H., Carlson, George A., Younkin, Steven G., Ashe, Karen H.
Publicado no J Neurosci (2002)

Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

Por Park, Laibaik, Uekawa, Ken, Bonilla, Lidia Garcia, Koizumi, Kenzo, Murphy, Michelle, Pistik, Rose, Younkin, Linda, Younkin, Steven, Zhou, Ping, Carlson, George, Anrather, Josef, Iadecola, Costantino
Publicado no Circ Res (2017)

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

Por Kawarabayashi, Takeshi, Shoji, Mikio, Younkin, Linda H., Wen-Lang, Lin, Dickson, Dennis W., Murakami, Tetsuro, Matsubara, Etsuro, Abe, Koji, Ashe, Karen Hsiao, Younkin, Steven G.
Publicado no J Neurosci (2004)

Environmental Enrichment Mitigates Cognitive Deficits in a Mouse Model of Alzheimer's Disease

Por Jankowsky, Joanna L., Melnikova, Tatiana, Fadale, Daniel J., Xu, Guilian M., Slunt, Hilda H., Gonzales, Victoria, Younkin, Linda H., Younkin, Steven G., Borchelt, David R., Savonenko, Alena V.
Publicado no J Neurosci (2005)

Association of Plasma Beta-Amyloid Level and Cognitive Reserve with Subsequent Cognitive Decline

Por Yaffe, Kristine, Weston, Andrea, Graff-Radford, Neill R., Satterfield, Suzanne, Simonsick, Eleanor M., Younkin, Steven G., Younkin, Linda H., Kuller, Lewis, Ayonayon, Hilsa N., Ding, Jingzhong, Harris, Tamara B.
Publicado em 2011

Plasma amyloid β and risk of Alzheimer’s disease in the Framingham Heart Study

Por Chouraki, Vincent, Beiser, Alexa, Younkin, Linda, Preis, Sarah Rosner, Weinstein, Galit, Hansson, Oskar, Skoog, Ingmar, Lambert, Jean-Charles, Au, Rhoda, Launer, Lenore, Wolf, Philip A, Younkin, Steven, Seshadri, Sudha
Publicado no Alzheimers Dement (2014)

Innate immunity receptor CD36 promotes cerebral amyloid angiopathy

Por Park, Laibaik, Zhou, Joan, Zhou, Ping, Pistick, Rose, El Jamal, Sleiman, Younkin, Linda, Pierce, Joseph, Arreguin, Andrea, Anrather, Josef, Younkin, Steven G., Carlson, George A., McEwen, Bruce S., Iadecola, Costantino
Publicado em 2013

Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β

Por Park, Laibaik, Wang, Gang, Zhou, Ping, Zhou, Joan, Pitstick, Rose, Previti, Mary Lou, Younkin, Linda, Younkin, Steven G., Van Nostrand, William E., Cho, Sunghee, Anrather, Josef, Carlson, George A., Iadecola, Costantino
Publicado em 2011

Persistent Amyloidosis following Suppression of Aβ Production in a Transgenic Model of Alzheimer Disease

Por Jankowsky, Joanna L, Slunt, Hilda H, Gonzales, Victoria, Savonenko, Alena V, Wen, Jason C, Jenkins, Nancy A, Copeland, Neal G, Younkin, Linda H, Lester, Henry A, Younkin, Steven G, Borchelt, David R
Publicado em 2005

Involvement of β-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity

Por Ma, Huifang, Lesné, Sylvain, Kotilinek, Linda, Steidl-Nichols, Jill V., Sherman, Mathew, Younkin, Linda, Younkin, Steven, Forster, Colleen, Sergeant, Nicolas, Delacourte, André, Vassar, Robert, Citron, Martin, Kofuji, Paulo, Boland, Linda M., Ashe, Karen H.
Publicado em 2007

Fine mapping of the α-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer’s disease pedigrees

Por Ertekin-Taner, Nilüfer, Ronald, James, Asahara, Hideaki, Younkin, Linda, Hella, Maria, Jain, Shushant, Gnida, Eugene, Younkin, Samuel, Fadale, Daniel, Ohyagi, Yasumasa, Singleton, Adam, Scanlin, Leah, de Andrade, Mariza, Petersen, Ronald, Graff-Radford, Neill, Hutton, Michael, Younkin, Steven
Publicado em 2003

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

Por Kotilinek, Linda A., Westerman, Marcus A., Wang, Qinwen, Panizzon, Kimberly, Lim, Giselle P., Simonyi, Agnes, Lesne, Sylvain, Falinska, Agnieszka, Younkin, Linda H., Younkin, Steven G., Rowan, Michael, Cleary, James, Wallis, Roi Ann, Sun, GraceY., Cole, Greg, Frautschy, Sally, Anwyl, Roger, Ashe, Karen H.
Publicado em 2008

Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer’s pathophysiology and susceptibility

Por Sevlever, Daniel, Zou, Fanggeng, Ma, Li, Carrasquillo, Sebastian, Crump, Michael G, Culley, Oliver J, Hunter, Talisha A, Bisceglio, Gina D, Younkin, Linda, Allen, Mariet, Carrasquillo, Minerva M, Sando, Sigrid B, Aasly, Jan O, Dickson, Dennis W, Graff-Radford, Neill R, Petersen, Ronald C, Belbin, Olivia
Publicado no Mol Neurodegener (2015)