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Altered Amyloid-β Metabolism and Deposition in Genomic-based β-Secretase Transgenic Mice
Amyloid-β (Aβ) the primary component of the senile plaques found in Alzheimer’s disease (AD) is generated by the rate-limiting cleavage of amyloid precursor protein (APP) by β-secretase followed by γ-secretase cleavage. Identification of the primary β-secretase gene, BACE1, provides a unique opportu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659546/ https://ncbi.nlm.nih.gov/pubmed/15452128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M409680200 |
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