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Spatial and temporal control of age-related APP processing in genomic-based β-secretase transgenic mice
Genetic mutations associated with Alzheimer’s disease (AD) in the Amyloid Precursor Protein (APP) gene specifically alter the production of the APP processing product, amyloid-β (Aβ) peptide, generated by β- and γ-secretases. The accumulation and deposition of Aβ is hypothesized to cause AD pathogen...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2659539/ https://ncbi.nlm.nih.gov/pubmed/16387391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2005.11.011 |
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