Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

Peptides derived from proteolytic processing of the β-amyloid precursor protein (APP), including the amyloid-β peptide (Aβ), play a critical role in the pathogenesis of Alzheimer's dementia. We report that transgenic mice overexpressing APP and Aβ have a profound attenuation in the increase in...

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Κύριοι συγγραφείς: Niwa, Kiyoshi, Younkin, Linda, Ebeling, Christine, Turner, Sherry K., Westaway, David, Younkin, Steven, Ashe, Karen Hsiao, Carlson, George A., Iadecola, Costantino
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The National Academy of Sciences 2000
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC16934/
https://ncbi.nlm.nih.gov/pubmed/10944232
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