Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

We studied the role of the amyloid precursor protein (APP) in ischemic brain damage using transgenic mice overexpressing APP. The middle cerebral artery (MCA) was occluded in FVB/N mice expressing APP(695).SWE (Swedish mutation) and in nontransgenic littermates. Infarct volume (cubic millimeters) wa...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhang, Fangyi, Eckman, Chris, Younkin, Steven, Hsiao, Karen K., Iadecola, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1997
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6793926/
https://ncbi.nlm.nih.gov/pubmed/9315887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.17-20-07655.1997
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