Transgenic Mice Overexpressing Amyloid Precursor Protein Exhibit Early Metabolic Deficits and a Pathologically Low Leptin State Associated with Hypothalamic Dysfunction in Arcuate Neuropeptide Y Neurons

Eitemau Tebyg

• Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction
  gan: Ishii, Makoto, et al.
  Cyhoeddwyd: (2019)
• Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein
  gan: Zhang, Fangyi, et al.
  Cyhoeddwyd: (1997)
• Overexpression of Heparanase Lowers the Amyloid Burden in Amyloid-β Precursor Protein Transgenic Mice
  gan: Jendresen, Charlotte B., et al.
  Cyhoeddwyd: (2015)
• Ablation of the Leptin Receptor in the Hypothalamic Arcuate Nucleus Abrogates Leptin-Induced Sympathetic Activation
  gan: Harlan, Shannon M., et al.
  Cyhoeddwyd: (2011)
• Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein
  gan: Seita, Yasunari, et al.
  Cyhoeddwyd: (2020)