Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction

Weight loss is an early manifestation of Alzheimer's disease that can precede the cognitive decline, raising the possibility that amyloid-β (Aβ) disrupts hypothalamic neurons critical for the regulation of body weight. We previously reported that, in young transgenic mice overexpressing mutated...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ishii, Makoto, Hiller, Abigail J., Pham, Laurie, McGuire, Matthew J., Iadecola, Costantino, Wang, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6820205/
https://ncbi.nlm.nih.gov/pubmed/31537707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0617-19.2019
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