Tau Loss Attenuates Neuronal Network Hyperexcitability in Mouse and Drosophila Genetic Models of Epilepsy

Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a component of some degenerative neurological disorders such as Alzheimer's disease (AD). Recently, the microtubule-binding protein tau has been implicated in the regulation of network synchronization. Genetic remo...

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Main Authors: Holth, Jerrah K., Bomben, Valerie C., Reed, J. Graham, Inoue, Taeko, Younkin, Linda, Younkin, Steven G., Pautler, Robia G., Botas, Juan, Noebels, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711605/
https://ncbi.nlm.nih.gov/pubmed/23345237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3191-12.2013
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