Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

We show here that the voltage-gated K(+) channel Kv12.2 is a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 significantly reduced firing threshold in these neurons. Kv12.2(−/−) mice displayed signs of persistent neuronal hyperexc...

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Detalhes bibliográficos
Main Authors: Zhang, Xiaofei, Bertaso, Federica, Yoo, Jong W., Baumgärtel, Karsten, Clancy, Sinead M., Lee, Van, Cienfuegos, Cynthia, Wilmot, Carly, Avis, Jacqueline, Hunyh, Truc, Daguia, Catherine, Schmedt, Christian, Noebels, Jeffrey, Jegla, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928878/
https://ncbi.nlm.nih.gov/pubmed/20676103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2610
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