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Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy
We show here that the voltage-gated K(+) channel Kv12.2 is a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 significantly reduced firing threshold in these neurons. Kv12.2(−/−) mice displayed signs of persistent neuronal hyperexc...
Gorde:
| Egile Nagusiak: | , , , , , , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2928878/ https://ncbi.nlm.nih.gov/pubmed/20676103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2610 |
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