Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides

RATIONALE: Increasing evidence indicates that alterations of the cerebral microcirculation may play a role in Alzheimer’s disease (AD), the leading cause of late-life dementia. The amyloid-β peptide (Aβ), a key pathogenic factor in AD, induces profound alterations in neurovascular regulation through...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Park, Laibaik, Uekawa, Ken, Bonilla, Lidia Garcia, Koizumi, Kenzo, Murphy, Michelle, Pistik, Rose, Younkin, Linda, Younkin, Steven, Zhou, Ping, Carlson, George, Anrather, Josef, Iadecola, Costantino
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522360/
https://ncbi.nlm.nih.gov/pubmed/28515043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311054
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