Extracellular matrix composition determines the transcriptional response to epidermal growth factor receptor activation

Por Yarwood, Stephen J., Woodgett, James R.
Publicado em 2001

The role of c-Jun in controlling the EPAC1-dependent induction of the SOCS3 gene in HUVECs

Por Wiejak, Jolanta, Dunlop, Julia, Yarwood, Stephen J.
Publicado em 2014

EPAC proteins transduce diverse cellular actions of cAMP

Por Borland, Gillian, Smith, Brian O, Yarwood, Stephen J
Publicado em 2009

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

Por Bird, Rebecca J., Baillie, George S., Yarwood, Stephen J.
Publicado em 2010

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal

Por Parnell, Euan, Smith, Brian O., Yarwood, Stephen J.
Publicado no Cell Signal (2015)

The future of EPAC-targeted therapies: agonism versus antagonism

Por Parnell, Euan, Palmer, Timothy M., Yarwood, Stephen J.
Publicado no Trends Pharmacol Sci (2015)

Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activati...

Por Wiejak, Jolanta, Dunlop, Julia, Mackay, Simon P., Yarwood, Stephen J.
Publicado em 2013

Activation of Protein Kinase Cα by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein β-dependent Induction of the SOCS-3 Gene by Cyclic AMP in COS1 Cells

Por Borland, Gillian, Bird, Rebecca J., Palmer, Timothy M., Yarwood, Stephen J.
Publicado em 2009

The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)

Por Wiejak, Jolanta, van Basten, Boy, Luchowska-Stańska, Urszula, Hamilton, Graham, Yarwood, Stephen J.
Publicado no Biochim Biophys Acta Mol Cell Res (2019)

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A

Por Magiera, Maria M., Gupta, Mona, Rundell, Catherine J., Satish, Nilima, Ernens, Isabelle, Yarwood, Stephen J.
Publicado em 2004

Regulation of the inflammatory response of vascular endothelial cells by EPAC1

Por Parnell, Euan, Smith, Brian O, Palmer, Timothy M, Terrin, Anna, Zaccolo, Manuela, Yarwood, Stephen J
Publicado em 2012

Genomic analysis of the role of transcription factor C/EBPδ in the regulation of cell behaviour on nanometric grooves

Por Wiejak, Jolanta, Tsimbouri, Penelope M., Herzyk, Pawel, Dalby, Matthew J., Hamilton, Graham, Yarwood, Stephen J.
Publicado em 2013

The Potential of a Novel Class of EPAC-Selective Agonists to Combat Cardiovascular Inflammation

Por Barker, Graeme, Parnell, Euan, van Basten, Boy, Buist, Hanna, Adams, David R., Yarwood, Stephen J.
Publicado no J Cardiovasc Dev Dis (2017)

Serine-727 Phosphorylation Activates Hypothalamic STAT-3 Independently From Tyrosine-705 Phosphorylation

Por Breit, Andreas, Besik, Valeria, Solinski, Hans Jürgen, Muehlich, Susanne, Glas, Evi, Yarwood, Stephen J., Gudermann, Thomas
Publicado no Mol Endocrinol (2015)

Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5

Por Bolger, Graeme B, McCahill, Angela, Yarwood, Stephen J, Steele, Michael R, Warwicker, Jim, Houslay, Miles D
Publicado em 2002

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F4...

Por MacKenzie, Simon J., Yarwood, Stephen J., Peden, Alexander H., Bolger, Graeme B., Vernon, Richard G., Houslay, Miles D.
Publicado em 1998

The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactiva...

Por Wiejak, Jolanta, Dunlop, Julia, Stoyle, Chloe, Lappin, Gillian, McIlroy, Anna, Pediani, John D., Gao, Shan, Yarwood, Stephen J.
Publicado em 2012

Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells

Por Parnell, Euan, Koschinski, Andreas, Zaccolo, Manuela, Cameron, Ryan T., Baillie, George S., Baillie, Gemma L., Porter, Alison, McElroy, Stuart P., Yarwood, Stephen J.
Publicado no Biochim Biophys Acta (2015)

Epac1 links prostaglandin E(2) to β-catenin-dependent transcription during epithelial-to-mesenchymal transition

Por Jansen, Sepp R., Poppinga, Wilfred J., de Jager, Wim, Lezoualc'h, Frank, Cheng, Xiaodong, Wieland, Thomas, Yarwood, Stephen J., Gosens, Reinoud, Schmidt, Martina
Publicado no Oncotarget (2016)

Identification of a Novel, Small Molecule Partial Agonist for the Cyclic AMP Sensor, EPAC1

Por Parnell, Euan, McElroy, Stuart P., Wiejak, Jolanta, Baillie, Gemma L., Porter, Alison, Adams, David R., Rehmann, Holger, Smith, Brian O., Yarwood, Stephen J.
Publicado no Sci Rep (2017)