The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun

Induction of the suppressor of cytokine signalling 3 (SOCS-3) gene is vital to the normal control of inflammatory signalling. In order to understand these processes we investigated the role of the proto-oncogene component of the AP-1 transcription factor complex, c-Jun, in the regulation of SOCS-3 g...

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Detalhes bibliográficos
Main Authors: Wiejak, Jolanta, Dunlop, Julia, Stoyle, Chloe, Lappin, Gillian, McIlroy, Anna, Pediani, John D., Gao, Shan, Yarwood, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383993/
https://ncbi.nlm.nih.gov/pubmed/22561846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.04.016
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